论文部分内容阅读
在水相中,采用化学共沉淀法以FeCl_3·6H_2O和FeSO_4·7H_2O为原料合成了超顺磁性Fe3O4纳米粒子,并以甘氨酸、甲基丙烯酸甲酯进行修饰。CdSe/CdS量子点以巯基乙酸为稳定剂制得。最后以乙二胺为联接剂成功制得磁性荧光双功能纳米微球。并利用荧光显微镜、荧光分光光度计、红外、透射电子显微镜(TEM)和振动样品磁强计(VSM)对该微粒进行表征。结果表明,该微粒分散性好,磁性强度高,荧光性能优异。再将其与牛血清白蛋白(BSA)一起培育,表明其生物相容性良好。磁性荧光双功能纳米材料有望在靶向治疗、免疫检测、细胞分离和催化等领域得到广泛应用。
In the aqueous phase, superparamagnetic Fe3O4 nanoparticles were synthesized by chemical coprecipitation using FeCl 3 · 6H 2 O and FeSO 4 · 7H 2 O as raw materials, and modified with glycine and methyl methacrylate. CdSe / CdS quantum dots with thioglycolic acid as stabilizer. Finally, ethylenediamine as coupling agent was successfully prepared magnetic fluorescent dual-function nanospheres. The particles were characterized by fluorescence microscopy, fluorescence spectrophotometer, infrared, transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM). The results show that the particles have good dispersion, high magnetic intensity and excellent fluorescence. It was then incubated with bovine serum albumin (BSA), indicating good biocompatibility. Magnetic fluorescent dual-functional nanomaterials are expected to be widely used in the fields of targeted therapy, immunoassay, cell separation and catalysis.