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20世纪20年代，德国生化学家瓦伯格发现即使在有氧条件下，肿瘤细胞也是通过糖酵解的方式获得生存必需的能量，这一现象被称为瓦伯格效应。然而，后续越来越多的研究发现并非所有的肿瘤中均存在瓦伯格效应，或者说并非所有的肿瘤细胞均存在瓦伯格效应。肿瘤细胞的代谢存在明显的多样性，部分细胞表现为糖酵解方式产能，另外一部分细胞表现为氧化磷酸化方式产能。两类细胞能够通过乳酸穿梭机制相互协调，和谐共处，即代谢共生。本文将就代谢共生的物质基础和细胞间的代谢共生现象，以及代谢共生对肿瘤细胞特性的影响及临床意义方面作一综述。希望通过对代谢共生的全面认识为设计全新而高效的治疗策略提供有益的帮助。“,”In the 1920s, German biochemist Warburg found that tumor cells used glycolysis for energy generation to maintain survival even under aerobic conditions, a phenomenon known as the Warburg effect. However, a growing number of studies have found that not all kinds of tumor showed the Warburg effect, or not all of tumor cells used the Warburg effect for energy generation. There is the diversity of metabolism in tumor cells. Some cells used glycolysis for energy production, but other cells used oxidative phosphoryla?tion for energy production. Two types of cells can mutually coordinate and coexist with each other through lactic acid shuttle system, which is named metabolic symbiosis. This review will discuss the material basis of metabolic symbiosis and symbiosis phenomenon a?mong cells in tumor. This review will also discuss the effect by metabolic symbiosis on characteristics of tumor cells and the clinical sig?nificance of metabolic symbiosis. A fully understanding of metabolic symbiosis in tumor cells is helpful for designing new and effective anti?cancer treatment strategies.