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目的：探讨膀胱灌注吡柔比星预防浅表性膀胱癌术后复发的疗效及安全性。方法：对116例浅表性膀胱癌患者行经尿道膀胱肿瘤电切术或膀胱部分切除术。术后1周开始用吡柔比星进行膀胱内定期灌注，每次药物在膀胱内保留30～60min。每周1次，连续8次，以后每月次，连续10次。并随访。结果：116例患者均未见全身性药物不良反应。仅9例患者出现轻微膀胱刺激症状。复发19例，复发率16．37％。结论：膀胱内灌注吡柔比星预防膀胱癌术后复发的疗效确切，不良反应少，安全性好，在灌药时加强对患者灌注前、灌注中及灌注后护理，可减轻患者不适感，提高患者灌药的依从性。“,”Objective To investigate the nursing of which bladderwas perfused Pirarubicin(THP)toprevent postoperative recurrence of su-perficial bladder cancer .Methods 116 cases of patients with superficialbladder cancer through transurethral resection of bladder tumor (TURbt)orpartial cystectomy .After postoperative one week ,30mgPirarubicin was dissolved into 40 ml of 5% glucose infusion bladder regu-larly ,combinationwith the necessary care before and after perfusion .Results 116 cases were not seen systemic adverse drugreactions .only nine cases of mild bladder stimulation symptoms in patients .19case recurrence of bladder cancer(16 .37% ) .Conclusion To the prevention of post-operative recurrenceof bladder cancer ,the bladder with THPperfusion combination with the care during the perfusion were the exactefficacy , safety ,w hichreduced discomfort of the patient ,andimproved the patients of compliance reperfusion .