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目的 :探讨五项肿瘤标志物联检对提高原发性肝癌 (PHC)的检出率和早期诊断的意义。方法 :以甲胎蛋白 (AFP)的检测为主体配合谷氨酰转肽酶 (γ GT)、α L 岩藻糖苷酶 (AFU)、肿瘤坏死因子 (TNF α)和DR 70 TM五项指标对原发性肝癌 50例、肝外恶性肿瘤和肝硬化及健康人各 30例进行了血清检测。结果 :原发性肝癌患者多项指标含量与正常组比较均有明显差异或非常显著差异 (P <0 0 5和P <0 0 1)。各项指标除DR 70 TM和TNF α标志物对肝外恶性肿瘤和肝硬化比较差异无显著性外 ,其余指标各组间比较均有显著或非常显著差异 (P <0 0 5和P <0 0 1)。结论 :应用多项指标联合检测PHC的诊断率可达 98% ,尤其可提高小肝癌 (直径≤ 5cm)的检出率
Objective: To explore the significance of the combined detection of five tumor markers for improving the detection rate and early diagnosis of primary liver cancer (PHC). METHODS: Five pairs of glutamyl transpeptidase (γ GT), α L fucosidase (AFU), tumor necrosis factor (TNF α), and DR 70TM were used as the main method for the detection of alpha-fetoprotein (AFP). Fifty cases of primary liver cancer, extrahepatic malignancies, and cirrhosis and 30 healthy persons each had serum tests. Results: There were significant differences or significant differences in the content of multiple indicators between patients with primary liver cancer and normal controls (P <0 05 and P <0 01). There were no significant differences between the indicators of DR 70 TM and TNF α markers in extrahepatic malignancies and cirrhosis, but there were significant or very significant differences among the other indicators (P <0 0 5 and P <0). 0 1). Conclusion: The diagnostic rate of combined detection of PHC using multiple indexes can reach 98%, especially for the detection of small liver cancer (diameter ≤ 5cm).