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目的 :探讨新生儿缺氧缺血性脑病 (HIE)脐血 IL- 6、TNF- α与 NO变化的临床意义。方法 :分别用放射免疫法与硝酸盐还原酶两点法检测了 4 0例 HIE患儿及 4 0例正常新生儿脐血 IL- 6、TNF- α与 NO水平。结果 :与正常新生儿比较 ,HIE患儿脐血 IL- 6水平分别为 70 .53± 18.86对 81.80± 2 7.96 pg/ ml(p=0 .0 38) ,TNF- a分别为 1.0 3± 0 .30±对 0 .82± 0 .31ng/ ml(p=0 .0 0 1) ,NO分别为59.17± 2 4 .11对 85.0 5± 31.36 μmol/ L(p=0 .0 0 1) ,而且病情越重改变越明显。结论 :围产期窒息与HIE患儿脐血 IL- 6与 NO水平减低 ,TNF- α水平升高 ,它们可能参与了新生儿缺氧缺血性脑损伤的某些发病过程 ,脐血免疫指标的检测可用于 HIE的早期预测。
Objective: To investigate the clinical significance of changes of IL-6, TNF-α and NO in neonatal hypoxic-ischemic encephalopathy (HIE). Methods: The levels of IL-6, TNF-α and NO in cord blood of 40 neonates with HIE and 40 normal neonates were detected by radioimmunoassay and nitrate reductase respectively. Results: Compared with normal neonates, the levels of IL-6 in cord blood of HIE children were 70.53 ± 18.86 vs 81.80 ± 2.796 pg / ml (p = 0.388) .30 ± 0.82 ± 0.31ng / ml (p = 0.0001), NO were 59.17 ± 2 4.11 and 85.0 5 ± 31.36 μmol / L, respectively And more serious changes in the more obvious. CONCLUSIONS: IL-6 and NO levels in umbilical blood and TNF-α levels are elevated in perinatal asphyxia and HIE children, which may be involved in some pathogenesis of neonatal hypoxic-ischemic brain damage. Can be used for the early prediction of HIE.