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目的大脑动脉环血流变化常与颈内动脉狭窄相联系。本研究试用有限元方法来研究颈内动脉狭窄对大脑动脉环内的血流动力学影响,以此探讨动脉环内交通动脉代偿机制。方法采用MIMICS10.0软件及ANSYS14.5软件,建立了一个包括血管和血流在内的流固耦合的三维有限元模型,模拟了健康模型(颈内动脉无狭窄)及各种病理模型(颈内动脉狭窄率分别为15%、30%、45%,60%、70%、80%和90%)。通过监测前交通动脉和后交通动脉内的血流变化,掌握动脉环内血流动力学的改变。结果包括血管和血流的流固耦合有限元模型首次得以建立。随着狭窄率增加,前交通动脉与患侧后交通动脉内血流逐渐增多,狭窄率达到90%后,两条血管内血流减少;健侧后交通动脉内血流也全程逐渐增加,但量极小,基本无明显变化。结论通过以上的结果可见,随着颈内动脉狭窄程度的加重,大脑动脉环通过前交通动脉与患侧后交通动脉开放达到代偿,狭窄率达到90%后代偿失效,从机制上印证了颈内动脉狭窄与颅内缺血性病变相关。
The purpose of the cerebral artery blood flow and carotid artery stenosis are often linked. In this study, the finite element method was used to study the influence of internal carotid artery stenosis on the hemodynamics in the cerebral artery rings, in order to explore the compensatory mechanism of traffic artery in the artery rings. Methods A three-dimensional finite element model of fluid-structure interaction, including blood vessels and blood flow, was established by using MIMICS10.0 software and ANSYS14.5 software. The three-dimensional finite element model of fluid-structure interaction was simulated. Internal stenosis rates were 15%, 30%, 45%, 60%, 70%, 80% and 90%, respectively). Hemodynamic changes in the arterial annulus are monitored by monitoring changes in blood flow in the anterior communicating artery and posterior communicating artery. The results include the establishment of a fluid-structure coupled finite element model of blood vessels and blood flow for the first time. With the increase of the stenosis rate, the blood flow in the anterior communicating artery and the posterior communicating artery gradually increased. After the stenosis rate reached 90%, the blood flow in the two vessels decreased. The blood flow in the contralateral posterior communicating artery also increased gradually, Very small amount, the basic no significant change. Conclusions From the above results, it can be seen that as the degree of internal carotid artery stenosis aggravates, the cerebral artery rings are compensated by the opening of the anterior communicating artery and the posterior communicating artery, and the stenosis rate is 90% Internal carotid artery stenosis is associated with intracranial ischemic lesions.