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目的:观察托吡酯加用治疗癫癎难治性部分性发作的疗效。方法:３２例难治性部分性发作或继发性全身性发作癫癎患者,病程１年以上,一直服用一种或两种基础抗癫癎药物每月仍有≥４次以上的发作。托吡酯采用加量法,加量期８周,目标剂量为２００ｍｇ·ｄ－１,观察１２周后进入延长期。结果:３２例病人经过治疗后,发作１００%消失者５例(１５．６２%),发作≤７５%１３例(４０．６２%),发作≤５０%１１例(３４．３７%),无改善２例(６．２５%),因不良反应而中断１例(２．１３%)。结论:托吡酯是一种非常有效的新型抗癫癎药物。
Objective: To observe the therapeutic effect of topiramate combined with intractable epilepsy partial seizures. Methods: Thirty-two patients with intractable paroxysmal or secondary generalized seizures were treated for one year or more. One or two kinds of basic antiepileptic drugs were taken once or twice a month. Topiramate dosage method, the amount of 8 weeks, the target dose of 200mg · d-1, observed after 12 weeks into the extension. Results: Thirty-two patients (15.62%) experienced 100% disappearance after operation, 13 patients (40.62%) had seizures ≤ 75%, 11 patients (34.37%) had seizures ≤ 50%, and none Two patients (6.25%) improved and one patient (2.13%) discontinued due to adverse reactions. Conclusion: Topiramate is a very effective new antiepileptic drug.