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为了拓展以甾体为模板的仿酶设计这一新的研究领域,探讨仿酶模型中的疏水作用,本文首次考查了雌甾-金属卟啉模型物对异丙苯的催化氧化性能。实验结果表明,具有刚性疏水结构的甾体组分引入金属卟啉中,使后者的催化活性显著提高,并且反应具有很高的区域选择性。从而说明了在仿酶模型中引入疏水结合部位或微环境至关重要,同时表明了引入甾体组分是提高金属卟啉催化活性的有效途径。本文还探讨了影响反应的
In order to expand the new research field of steroid-like biomimetic design and to explore the hydrophobic interaction in the biomimetic model, the catalytic oxidation of cumene with metalloporphyrin was investigated for the first time. The experimental results show that the steroid component with rigid hydrophobic structure is introduced into metalloporphyrin, which results in a marked increase of the catalytic activity of the latter, and the reaction has a high regioselectivity. Thus, it is important to introduce hydrophobic binding sites or microenvironment into the biomimetic enzyme model. At the same time, the introduction of steroid components is an effective way to improve the catalytic activity of metalloporphyrins. This article also explored the impact of response