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目的探讨VEGF、MMP-9在良性与侵袭性骨巨细胞瘤组织中的表达差异及临床意义。方法采用免疫组织化学方法检测分析VEGF、MMP-9在13例良性与11例侵袭性骨巨细胞瘤组织表达差异。结果 VEGF、MMP-9在侵袭性骨巨细胞瘤组织表达增强,同一肿瘤内部通常边缘较中心部位表达强,两者相比较有明显差别(P<0.05)。结论 VEGF、MMP-9表达增强及其协同作用可能导致骨巨细胞瘤有较强侵袭,可能与骨巨细胞瘤发生、发展、转移密切相关,联合检测VEGF、MMP-9有助骨巨细胞瘤患者治疗和预后判断。
Objective To investigate the difference and clinical significance of VEGF and MMP-9 in benign and invasive giant cell tumor of bone. Methods Immunohistochemistry was used to detect the expression of VEGF and MMP-9 in 13 cases of benign and 11 giant cell tumor of bone. Results The expressions of VEGF and MMP-9 were significantly increased in invasive giant cell tumor of bone, and the expression of VEGF and MMP-9 was stronger in the center than that in the central part of the same tumor. There was a significant difference between the two groups (P <0.05). Conclusions The enhanced expression of VEGF and MMP-9 and their synergistic effect may lead to the strong invasion of giant cell tumor of bone, which may be closely related with the occurrence, development and metastasis of giant cell tumor of bone. Combined detection of VEGF and MMP-9 contributes to the treatment of giant cell tumor of bone Patient treatment and prognosis.