Correlation between synaptic protein expression and synaptic reorganization in the hippocampal CA3 r

• 出 处: Neural Regeneration Research
• 发表日期: 2010年15期
• 关键词: epilepsy reorganization synaptic hippocampal traumatic synaptophysin sprouting s

Postsynaptic density protein-95 and synaptophysin participate in synaptic reorganization in the forebrain of epilepsy models.However,the time-effect relationship between dynamic synapsin expression in hippocampus and synaptic reorganization in the post-traumatic epilepsy model remains unclear.FeCl2 was injected into the hippocampal CA3 region of the right forebrain in rats to induce post-traumatic epilepsy.Postsynaptic density protein-95 and synaptophysin expression was detected using immunohistochemistry.Epileptiform discharge induced by FeCl2 injection was determined in rat forebrain neurons,revealing decreased postsynaptic density protein-95 expression at 24 hours and lowest levels at 7 days.Synaptophysin expression was markedly reduced at 24 hours,but increased at 7 days.Postsynaptic density protein-95 and synaptophysin expression was consistent with abnormal mossy fiber sprouting and synaptic reorganization following neuronal injury in the hippocampal CA3 region of FeCl2-induced epilepsy models.

Postsynaptic density protein-95 and synaptophysin participate in synaptic reorganization in the forebrain of epilepsy models. Despite, the time-effect relationship between dynamic synapsin expression in hippocampus and synaptic reorganization in the post-traumatic epilepsy model remains unclear. FeCl2 was injected into the hippocampal CA3 region of the right forebrain in rats to induce post-traumatic epilepsy. Post synaptic density expression-95 and synaptophysin expression was detected using immunohistochemistry. Epileptiform discharge induced by FeCl2 injection was determined in rat forebrain neurons, revealing decreased postsynaptic density protein-95 expression at 24 hours and lowest levels at 7 days. Synaptophysin expression was markedly reduced at 24 hours, but increased at 7 days. Postsynaptic density protein-95 and synaptophysin expression was consistent with abnormal mossy fiber sprouting and synaptic reorganization following neuronal injury in the hippocampal CA3 region of FeCl2-induced e pilepsy models.