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目的:研究α-细辛醚黏胶分散型经皮贴剂制备及其体外释放及透皮性质。方法:采用Eudragit E100为压敏胶材料制备α-细辛醚黏胶分散型贴剂,并筛选出最佳贴剂处方,进行黏附性和释放试验研究,并用Franz扩散池体外评价不同透皮促渗剂对皮肤的渗透情况。结果:所筛选得到药物黏胶分散型贴剂对皮肤无刺激性,合用油酸和肉豆蔻酸异丙酯可显著提高贴剂的透皮效果,药物最大渗透速率为(1.41±0.20)μg·cm-2·h-1。结论:以Eudragit E100为压敏胶材料,油酸、肉豆蔻酸异丙酯为联合促渗剂,制得的α-细辛醚的黏胶分散型经皮贴剂,有望满足临床的治疗要求。
Objective: To study the preparation, in vitro release and transdermal properties of α-asarone-dispersed transdermal patch. METHODS: The α-arachisone viscose dispersive patch was prepared by using Eudragit E100 as a pressure-sensitive adhesive material, and the best patch preparation was screened out. The adhesion and release test were studied, and different transdermal stimulation was evaluated in vitro using a Franz diffusion cell. Penetrant skin penetration. RESULTS: The drug-dispersed patch obtained was not irritating to the skin. The combination of oleic acid and isopropyl myristate significantly improved the transdermal effect of the patch. The maximum penetration rate of the drug was (1.41±0.20) μg. Cm-2·h-1. Conclusion: The adhesive-dispersed transdermal patch of α-asarone prepared with Eudragit E100 as the pressure-sensitive adhesive material, oleic acid and isopropyl myristate as the joint penetration enhancer is expected to meet the clinical treatment requirements. .