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目的：比较长链脂肪乳剂（ＬＣＴ）和中链脂肪乳剂（ＭＣＴ）在急性缺血性肾功能衰竭大鼠中的代谢特点。方法：大鼠分成ＬＣＴ正常组、ＬＣＴ肾衰组、ＭＣＴ正常组和ＭＣＴ肾衰组。从尾静脉注射０．３ｇ／ｋｇ的１０％英脱利匹（ＬＣＴ）和１０％力波肪定（ＭＣＴ），在注射后２、１０、４０、７０、１００、１３０及１６０分钟测血甘油三酯浓度以行药代动力学分析。结果：ＬＣＴ在肾衰组中的清除速率常数（Ｋｅ）明显小于正常组，半衰期（ｔ１／２）则明显大于正常组。ＭＣＴ在肾衰组的Ｋｅ和ｔ１／２与正常组相比无明显差异。在正常组中，ＬＣＴ的Ｋｅ较ＭＣＴ明显减少，而ｔ１／２则明显延长。在肾衰组中，ＬＣＴ的Ｋｅ较ＭＣＴ进一步减小，ｔ１／２则更明显延长。２组ＭＣＴ组的大鼠血清胰岛素均较ＬＣＴ组有明显升高。结论：ＭＣＴ在肾衰大鼠体内被清除速度快，能促进胰岛素的分泌，有助于改善急肾衰时的氮平衡。ＭＣＴ在急肾衰中的应用较ＬＣＴ更为优越
OBJECTIVE: To compare the metabolic characteristics of long-chain lipid emulsion (LCT) and medium-chain fat emulsion (MCT) in acute ischemic renal failure rats. Methods: The rats were divided into normal LCT group, LCT renal failure group, normal MCT group and MCT renal failure group. 0.3 g / kg of 10% methotrexate (LCT) and 10% levobupivacaine (MCT) were injected from the tail vein, and blood glucose was measured at 2, 10, 40, 70, 100, 130 and 160 minutes after injection The triester concentration was determined by pharmacokinetics. Results: The clearance rate (LC) of LCT in renal failure group was significantly lower than that in normal group, and the half-life (t1 / 2) was significantly higher than that in normal group. MCT in renal failure group Ke and t1 / 2 compared with the normal group no significant difference. In the normal group, Ke compared with MCT LC significantly decreased, while t1 / 2 was significantly prolonged. In renal failure group, the LC of Ke was further reduced than MCT, t1 / 2 is more significantly longer. Serum insulin in 2 MCT groups was significantly higher than that in LCT group. Conclusion: MCT is rapidly cleared in rats with renal failure, which can promote the secretion of insulin and help to improve the nitrogen balance in acute renal failure. The application of MCT in acute renal failure is more superior than LCT