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口服人参茎叶皂甙25mg/kg,连续服用7天组小鼠心肌 cAMP 含量显著升高(p<0.01),而对 cGMP 含量无明显影响;50mg/kg GSL 对 cAMP,cGMP 含量均无明显影响。对利血平化小鼠,50mg/kg 能明显提高小鼠心肌中 cAMP 的含量(p<0.01),对 cGMP 含量影响不明显。cAMP/cGMP 比值提示,25mg/kg 和50mg/kg GSL 对 cAMP/cGMP 比值均增高;对利血平化小鼠心肌 cAMP/cGMP 比值无明显变化。
Oral ginseng stem and leaf saponin 25mg/kg, continuous administration of 7 days group mice myocardial cAMP content was significantly increased (p <0.01), while no significant impact on cGMP content; 50mg/kg GSL had no significant effect on cAMP, cGMP content. In mice treated with reserpine, 50 mg/kg significantly increased cAMP content in myocardium (p<0.01), but had no significant effect on cGMP content. The ratio of cAMP/cGMP suggested that the cAMP/cGMP ratio was increased at 25 mg/kg and 50 mg/kg GSL; there was no significant change in the cAMP/cGMP ratio of the myocardium in mice.