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Notch信号通路在进化上高度保守,在动物胚胎发育中起调控细胞命运的决定作用[1].Notch信号途径主要由3部分组成,即Notch受体、Noth配体以及CSL DNA结合蛋白.在哺乳动物体内共发现4种Notch受体基因(命名Notch1~4)和5种配体,包括Jagged1,Jagged2,DLL1,DLL3和DLL4.Notch受体是由Notch基因编码的单链跨膜蛋白,为多肽链构成的异二聚体分子,而Notch配体也是表达于细胞表面的单跨膜蛋白.相邻细胞通过
Notch signaling pathway is highly evolutionarily conserved and plays a decisive role in the control of cell fate in animal embryonic development.1 The Notch signaling pathway consists of three components, the Notch receptor, the Noth ligand, and the CSL DNA binding protein, Four Notch receptor genes (named Notch 1-4) and five ligands, including Jagged1, Jagged2, DLL1, DLL3 and DLL4, were found in animals, and the Notch receptor is a single-stranded transmembrane protein encoded by the Notch gene. Chain composed of heterodimeric molecules, and Notch ligand is also expressed on the cell surface of the transmembrane protein adjacent cells by