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少菌型麻风的带菌量估计低于10~5,因此其耐药突变问题并不重要.另外此类病人治疗后剩下的持久菌都可受到接近正常的细胞中介免疫力的遏制。所以对他们实行有限时间的联合化疗是可行的。麻风的治疗时间是任意确定的,而且很长,因为无人确知该何时停药.对T型,Lowe建议治24个月,而Whate则说应治2～5年。WHO的第三和第四次专家会议建议治18个月,直到病情停止活动。Girahar等证明18个月的治疗也不能减少复发。1982年WHO研究组提出用每月
Less bacteremic leprosy is estimated to be less than 10 to 5, so the problem of resistance mutations is not significant, and the remaining persistent bacteria in such patients may be held back by nearly normal cell-mediated immunity. So for them a limited time combined chemotherapy is feasible. Treatment time for leprosy is arbitrary and long, as no one knows when to stop taking the drug, and for T-type Lowe recommends 24 months, while Whate says it should be done for 2 to 5 years. The third and fourth expert meetings of the WHO recommend treatment for 18 months until their condition ceases. Girahar et al. Demonstrated that 18 months of treatment did not reduce relapse. In 1982, the WHO study group proposed to use monthly