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目的观察丹红注射液和厄贝沙坦治疗早期糖尿病肾病(DN)的效果。方法将69例早期糖尿病患者随机分为A、B、C三组,在常规治疗基础上,A组分别予丹红注射液30mL加入生理盐水250mL静脉滴注,1次/d;B组厄贝沙坦150mg口服1次/d;C组联用丹红注射液和厄贝沙坦,三组疗程均为4周。结果血压:治疗后B、C两组比治疗前显著下降,(P<0.01),A组治疗前后无明显变化;24h尿白蛋白排泄率和肾功能:3组治疗后均比治疗前显著下降(P<0.01),且C组下降优于A、B两组(P<0.05),有统计学意义。结论丹红注射液和厄贝沙坦治疗DN有减少蛋白尿,改善肾功能的功效。
Objective To observe the effect of Danhong injection and irbesartan on early diabetic nephropathy (DN). Methods Ninety-nine patients with early-stage diabetes were randomly divided into three groups: A, B and C. On the basis of conventional treatment, 30 mL of Danhong injection and 250 mL of normal saline were intravenously instilled once a day in group A, Saxan 150mg orally once / d; C group with Danhong injection and irbesartan, three courses were 4 weeks. Results Blood pressure: After treatment, B and C groups decreased significantly (P <0.01), A group had no significant changes before and after treatment; 24h urinary albumin excretion rate and renal function: the three groups were significantly decreased after treatment than before treatment (P <0.01), and the decline in group C was better than that in group A and B (P <0.05), with statistical significance. Conclusion Danhong injection and irbesartan treatment of DN have the effect of reducing proteinuria and improving renal function.