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以MTT法测定了46例肝硬化及40例正常对照周围血肿瘤坏死因子水平,旨在了解肝硬化TNFα水平及其与肝损伤的关系。结果肝硬化组TNFα水平(34.38±10.28u/ml/ml)与正常对照组(20.30±3.24u/ml)比较有统计学意义(P<0.001);资料还表明TNFα水平与AST/ALT及血清胆红素浓度有正相关关系(分别是r=0.632,P<0.001和r_s=0.683,P<0.001)。提示肝硬化TNFα浓度异常升高,并可能在肝细胞损伤的发病机制中起一定的作用。
The levels of TNF-α in 46 cases of cirrhosis and 40 cases of normal control were determined by MTT assay in order to understand the relationship between the level of TNFα in liver cirrhosis and liver injury. Results The level of TNFα in cirrhotic patients was significantly higher than that in normal controls (34.38 ± 10.28u / ml / ml vs 20.30 ± 3.24u / ml, P <0.001) There was a positive correlation between bilirubin concentrations (r = 0.632, P <0.001 and r_s = 0.683, P <0.001, respectively). Suggesting abnormally elevated levels of TNFα in cirrhosis and may play a role in the pathogenesis of hepatocellular injury.