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目的：探讨利培酮与氯氮平对精神分裂症患者体质量及糖脂代谢的影响。方法将92例精神分裂症患者随机分为两组，分别口服利培酮、氯氮平治疗，观察12周。于治疗前后采用阳性与阴性症状量表评定临床疗效，同时检测身高、体质量、腰围及空腹血糖、血脂水平的变化。结果治疗后两组阳性与阴性症状量表评分均较治疗前显著下降（P＜0.01），两组总有效率比较差异无显著性（ P＞0.05）。治疗12周末两组体质量指数、空腹血糖、总胆固醇、三酰甘油水平均较治疗前显著升高（ P＜0.05或0.01）；氯氮平组体质量指数及空腹血糖水平较利培酮组升高更显著（P＜0.01），总胆固醇、三酰甘油水平高于利培酮组，但差异无显著性（P＞0.05）。结论利培酮与氯氮平治疗精神分裂症疗效显著且相当，但对患者的体质量、糖脂代谢均有不同程度的影响，氯氮平的影响更明显，临床治疗中应密切监视各项代谢指标的变化。“,”Objective To explore effects of risperidone and clozapine on schizophrenic’s body mass and glu‐colipid metabolism .Methods Ninety‐two schizophrenics were randomly assigned to two groups taking o‐rally risperidone or clozapine for 12 weeks .Before and after treatment efficacies were assessed with the Positive and Negative Syndrome Scale (PANSS) ,meanwhile the changes of body height ,body mass ,waist circumference as well as fasting blood glucose and fat levels detected .Results After treatment the PAN‐SS scores of both groups lowered more significantly compared with pre‐treatment (P0.05) .At the end of the 12th week body mass in‐dex (BMI) ,fasting blood glucose (FBG) ,total cholesterol and triacylglycerol level heightened more sig‐nificantly compared with pretreatment (P<0.05 or 0.01);the BMI and FBG level heightened more signif‐icantly in clozapine than risperidone group (P0.05) .Conclusion Risperi‐done has an evident effect equivalent to clozapine in schizophrenia ,but both have different influences on BMI and glucolipid metabolism ,especially clozapine ,and changes of each metabolism index should be closely monitored in clinic .