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本研究目的在于探讨大鼠氧惊厥时,纹状体和下丘脑内亮-脑啡肽(L-Enk)含量的变化。实验中将32只雄性大鼠随机分为4组:常压空气组、高压常氧氮组、高压氧未惊厥组和高压氧惊厥组。用放射免疫法测定了纹状体和下丘脑内L-Enk含量。结果显示,在高压氧环境中暴露的大鼠纹状体和下丘脑内L-Enk含量明显高于常压空气组和高压常氧氮组;且增高到一定水平时发生惊厥。实验结果提示,动物惊厥与纹状体和下丘脑中L-Enk含量的增加呈正相关,而与高压氧环境及加减压方式无显著关系。
The aim of this study was to investigate the changes of L-Enk in striatum and hypothalamus during oxygen-induced convulsion in rats. 32 male rats were randomly divided into 4 groups: normal air group, high pressure normoxemia group, hyperbaric oxygen non-convulsion group and hyperbaric oxygen convulsion group. The contents of L-Enk in the striatum and hypothalamus were measured by radioimmunoassay. The results showed that the content of L-Enk in striatum and hypothalamus exposed to hyperbaric oxygen environment was significantly higher than those in the normal-pressure air group and the high-pressure normoxemia group; and convulsions increased to a certain level. The experimental results suggest that animal convulsions are positively correlated with the increase of L-Enk content in the striatum and hypothalamus, but not with the hyperbaric oxygen environment and the mode of decompression and decompression.