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目的:比较干扰素与阿昔洛韦治疗急性疱疹性龈口炎的临床疗效。方法:将急性疱疹性龈口炎患者随机分为两组:干扰素组(58例)用重组人干扰素a 2b注射液100万IU肌注,1次/d,并用该药涂抹病损处。阿昔洛韦组(50例)口服阿昔洛韦片100～200 mg,5次/d,碘甘油涂抹病损处,观察疼痛及牙龈充血程度,溃疡数目变化及愈合时间。结果:同阿昔洛韦组相比,干扰素组疼痛及牙龈充血程度显著减轻,溃疡数目在1～3 d内显著减少,溃疡愈合时间短(3～5 d),有显著性差异(P<0.05)。结论:干扰素治疗急性疱疹性龈口炎具有疗程短,易于被患者接受,且无明显毒副作用,临床疗效确切。
Objective: To compare the clinical efficacy of interferon and acyclovir in the treatment of acute herpetic gingivalitis. Methods: The patients with acute herpetic gingivalis were randomly divided into two groups: Interferon group (58 cases) with recombinant human interferon a 2b injection of 1 million IU intramuscular injection, 1 times / d, and the drug smear lesions . Acyclovir group (50 cases) were given acyclovir orally 100-200 mg for 5 times a day. The lesions were treated with iodine glycerol, the degree of hyperemia, the number of ulcer and the healing time were observed. Results: Compared with the acyclovir group, the pain and gingival hyperemia in the interferon group were significantly reduced. The number of ulcers was significantly reduced within 1 ~ 3 days and the healing time of ulcer was short (3 ~ 5 days) (P <0.05). Conclusion: The treatment of acute herpetic gingivostomatitis with interferon has a short course of treatment, easy to be accepted by patients, and no obvious side effects, the clinical curative effect is exact.