论文部分内容阅读
作者选择26名18～36月龄感染过呼吸道合胞病毒(RSV)的健康儿童,用双盲法随机分为两组,疫苗组肌注0.5ml(50μg蛋白)疫苗,含90％～95％纯化的RSVF蛋白(PFP-1),对照组注射等量盐水,于接种后不同时间采血,用ELISA检测抗RSV糖蛋白F、Ga和Gb抗体,用空斑中和试验测定中和抗体,分析血清抗体应答与监测期间感染RSV的关系。
Twenty-six healthy children infected with respiratory syncytial virus (RSV) aged 18-36 months were selected and randomly divided into two groups by double-blind method. The vaccine group was intramuscularly injected with 0.5ml (50μg protein) vaccine containing 90% -95% The purified RSVF protein (PFP-1) was injected into the control group, and the control group was injected with the same amount of saline. Blood samples were collected at different times after inoculation. The anti-RSV glycoprotein F, Ga and Gb antibodies were detected by ELISA, neutralizing antibody by plaque neutralization assay, Serum Antibody Response to RSV During Monitoring.