Synthesis of a highly hydrophobic cyclic decapeptide by solid-phase synthesis of linear peptide and

• 作 者: Chen Jian Zhang Bei Xie Cao
• 机 构: FudanUniv
• 出 处: 中国化学快报：英文版
• 发表日期: 2010年4期
• 基金项目: supported by National Natural Science Foundation(No.30672546),, Shanghai Municipal Committee of S & T(No.0652nm013),, National Key Basic Research Program of China(No.2007CB935800)

A general method was described to synthesize a highly hydrophobic cyclic peptide,cyclo[LWLWLWLWLQ]where underlines indicate D-configuration of the amino acid,by a two-step solid-phase/solution synthesis strategy.The linear decapeptide was assembled by sta