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目的:探讨双相气道正压通气(BiPAP)无创呼吸机联合呼吸兴奋剂治疗急性加重期慢性阻塞性肺疾病(AECOPD)并Ⅱ型呼吸衰竭的效果。方法:抽取2018年1月至2020年1月太原钢铁(集团)有限公司总医院收治的AECOPD合并Ⅱ型呼吸衰竭患者84例，依据治疗方案将其分为两组，每组42例。对照组给予BiPAP无创呼吸机治疗，观察组在对照组基础上联合呼吸兴奋剂治疗。回顾性对照分析两组治疗效果及血气分析指标、围术期相关指标值。结果:治疗后，观察组总有效率为90.48%(38/42)，高于对照组的73.81%(31/42)，n P<0.05。治疗后，观察组患者pH值、血氧分压水平高于对照组(n t＝3.923、4.988，n P<0.05)，血二氧化碳分压水平低于对照组(n t＝5.817，n P<0.05)。观察组通气时间、住院时间少于对照组(n t＝5.833、6.258，n P<0.05)，观察组格拉斯哥昏迷量表评分高于对照组(n t＝8.011，n P<0.05)。n 结论:BiPAP无创呼吸机联合呼吸兴奋剂治疗AECOPD并Ⅱ型呼吸衰竭可提高总有效率，改善血气指标，缩短通气及康复时间。“,”Objective:To investigate the effect of biphasic positive airway pressure (BiPAP) non-invasive ventilator combined with respiratory stimulants in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with type II respiratory failure.Methods:A total of 84 patients with AECOPD and type II respiratory failure diagnosed and treated in General Hospital of Taiyuan Iron and Steel Group from January 2018 to January 2020 were divided into two groups according to the treatment plan, with 42 case in each group. The control group was treated with BiPAP non-invasive ventilator, and the observation group was treated with respiratory stimulants on the basis of the control group. The treatment effect, blood gas analysis index and perioperative related index values were compared and analyzed between the two groups retrospectively.Results:After treatment, the total effective rate of the observation group was 90.48% (38/42), which was higher than 73.81% (31/42) of the control group, n P<0.05. After treatment, the observation group had higher pH and blood oxygen partial pressure levels than those of the control group (n t=3.923, 4.988, n P<0.05), and blood carbon dioxide partial pressure levels was lower than that of the control group (n t=5.817, n P<0.05). The ventilation time and hospital stay of the observation group were less than those of the control group (n t=5.833, 6.258, n P<0.05), and the glasgow coma scale score of the observation group was higher than that of the control group (n t=8.011, n P<0.05).n Conclusions:BiPAP non-invasive ventilator combined with respiratory stimulant for AECOPD and type II respiratory failure can increase the total effective rate, improve blood gas indicators, and shorten the ventilation and recovery time.