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近年,有关端粒酶与恶性肿瘤相关性的研究已经成为肿瘤分子生物学领域最热门的课题之一〔1〕。在正常人体组织中除生殖细胞和部分造血干细胞显示弱端粒酶活性外,均无端粒酶活性,而恶性肿瘤细胞中端粒酶却特异性表达。1 端粒的结构与功能端粒是指真核细胞线性染色体末端的一种特
In recent years, research on the correlation between telomerase and malignancy has become one of the most popular topics in the field of molecular biology of cancer [1]. In normal human tissues, except for the germ cells and some hematopoietic stem cells showing weak telomerase activity, there was no telomerase activity, whereas telomerase was specifically expressed in malignant tumor cells. 1 Telomere structure and function Telomere refers to a special type of linear chromosome at the end of eukaryotic cells.