论文部分内容阅读
Objective:To explore the relationship between expressions of NF-κBp50,p53 and Bcl-2 in tissue of cervical can-cer and human papillomavirus(HPV)infection.Methods:The expressions of NF-κBp50,p53 and Bcl-2 were detected using immuohistochemical staining in 46 specimens of cervical cancer and 26 specimens of normal cervical tissue.The infection of HPV DNA were determined by PCR.Results:The expressions of NF-κBp50,p53 and Bcl-2 in tissue of cervical cancer were significantly higher than that in normal cervical tissue(P<0.01),and the expressions of NF-κBp50 and p53 or Bcl-2 were closely related(P<0.05).The expression of NF-κBp50 in HPV DNA positive group was significantly higher than that in HPV negative group(P<0.05),but there were no significantly differences in the expressions of p53 and Bcl-2 between HPV DNA positive group and HPV negative group(P>0.05).Conclusion:The expressions of NF-κBp50,p53 and Bcl-2 were significantly correlated with cervical carcinogenesis.NF-κBp50 may be activated by HPV infection.
Objective: To explore the relationship between expressions of NF-κBp50, p53 and Bcl-2 in tissue of cervical can-cer and human papillomavirus (HPV) infection. Methods: The expressions of NF-κBp50, p53 and Bcl-2 were detected using Immuohistochemical staining in 46 specimens of cervical cancer and 26 specimens of normal cervical tissue. The HPV of the HPV DNA were determined by PCR. Results: The expressions of NF-κBp50, p53 and Bcl-2 in tissue of cervical cancer were significantly higher than that (P <0.01), and the expressions of NF-κBp50 and p53 or Bcl-2 were closely related (P <0.05). The expression of NF-κB p50 in HPV DNA positive group was significantly higher than that in HPV Negative groups (P <0.05), but there were no significant differences in the expressions of p53 and Bcl-2 between HPV DNA positive group and HPV negative group (P> 0.05) .Conclusion: The expressions of NF-κBp50, p53 and Bcl -2 were significantly correlated with cervical carcinogenesis. NF-κB p50 may be a ctivated by HPV infection.