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本文采用组织胺刺激分泌及胃的活体组织检查法,研究慢性二硫化碳(CS_2)中毒病人胃粘膜的形态学病变,并与其分泌机能相比较。病人组包括41例,女性,平均年龄38岁,病史可排除发生胃肠道病理改变的非职业因素(吸烟、饮酒、患过严重疾病和长期破坏饮食制度)。对照组40例也为女性,年龄相近,胃粘膜组织正常,不接触职业有害物质,身体健康。胃分泌机能的评价用组织胺试验法:病人按每10公斤体重0.1 mg的剂量皮下注入0.1%盐酸组织胺溶液后,在1小时内用注射器不断地抽吸胃液,测定每15分钟所得胃液的总酸度及游离盐酸,并计算1小时的分泌量,根据总酸度的数值计算盐酸的每小时流出量。
In this paper, histamine stimulation and gastric biopsy were used to study the morphological changes of gastric mucosa in patients with chronic carbon disulfide poisoning (CS_2) and compared with its secretion function. The patient group consisted of 41 women and a mean age of 38 years. The medical history excluded non-occupational factors (smoking, alcohol consumption, serious illness, and chronic disruption of the diet) that caused the pathological changes in the gastrointestinal tract. The control group of 40 patients were also women, similar in age, normal gastric mucosa, do not come into contact with occupational harmful substances, good health. Histamine test: The patient was subcutaneously injected with 0.1% histamine solution in an amount of 0.1 mg per 10 kg of body weight, and the gastric juice was continuously aspirated with a syringe within 1 hour, and the volume of gastric juice obtained every 15 minutes Total acidity and free hydrochloric acid, and calculate the secretion of 1 hour, according to the total acidity of the value of the hourly outflow of hydrochloric acid.