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最近,羟基吡啶羧酸类抗菌剂的研究突然增多起来。Enoxacin(AT-2266)就是大日本制药公司开发的新抗菌剂。其化学名为1-乙基-6-氟-1,4-二氢-4-氧代-7-(1-哌嗪基)-1,8-萘啶-3-羧酸3/2水合物。本品对革兰氏阳性菌、革兰氏阴性菌包括沙雷氏菌、绿脓杆菌、非葡萄糖酵解菌以及支原体等均具有抗菌作用。特别对革兰氏阴性菌,其抗菌作用强于庆大霉素。口服本品后,消化道吸收快且具有良好的脏器移行性。本品吸收后大部份不发生代谢,一部份变成氧化物。血中半衰期为4～6小时,24小时内约有65％从尿中排泄。
Recently, the study of hydroxypicolinic acid antibacterial agents suddenly increased. Enoxacin (AT-2266) is a new antibacterial agent developed by Dainippon Pharmaceuticals. Its chemical name is 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7- (1-piperazinyl) -1,8-naphthyridine-3- Things. This product is Gram-positive bacteria, Gram-negative bacteria including Serratia bacteria, Pseudomonas aeruginosa, non-glycolytic bacteria and mycoplasma Dengjun have antibacterial effect. In particular, Gram-negative bacteria, its antibacterial effect stronger than gentamicin. After oral administration of this product, the digestive tract absorbs quickly and has good organ transplants. After absorption of most of this product does not occur metabolism, part of the oxide. Blood half-life of 4 to 6 hours, about 65% within 24 hours from the urine excretion.