Synthesis and Antitumor Activities of 26-O-tert-Butyldimethylsiliyl Protodisogenyl β-D-Glucopyranosi

• 出 处: Chinese Chemical Letters
• 发表日期: 2006年05期
• 关键词: saponins moiety antitumor medicines pharmaceutical pyranoside acetyl potent tran

New saponin 26-O-tert-butyldimethylsiliyl protodiosgenyl β-D-glucopyranoside 1 was synthesized and its cytotoxicity activity in vitro was evaluated by MTT. It showed potent antitumor activity to human cancer cells. E ring and C22-OH play important roles in the antitumor activity of 1. A method to selective removal of acetyl group in the presence of benzoyl group was reported.

New saponin 26-O-tert-butyldimethylsiliyl protodiosgenyl β-D-glucopyranoside 1 was synthesized and its cytotoxicity activity in vitro was evaluated by MTT. It showed potent antitumor activity to human cancer cells. E ring and C22-OH play important roles in the Antitumor activity of 1. A method to selective removal of acetyl group in the presence of benzoyl group was reported.