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为了确定糖尿病性肾病变的临床病程,作者对112 例伴肾病变的少年型糖尿病患者进行了回顾性分析。本组患者的糖尿病发病平均年龄为12±8岁,发生蛋白尿时的糖尿病平均病期为17.3±6.0年,发生蛋白尿后2年出现早期肾功能衰竭,发生蛋白尿后4年出现严重肾功能衰竭(平均血清肌酐浓度8.5±3.9毫克％)。发生蛋白尿后平均生存时间为4.8年(最长为13.3年)。发生早期肾功能衰竭后平均生存时间为2.7年(最长为5.7年)。发生严重肾功能衰竭后平均生存时间为6个月。本组患者的死亡率为53％,致死病例的59％死于肾功能衰竭,36％死于心血管疾患。全部患者都发生进行性肾功能恶化和糖尿病的其它并
To determine the clinical course of diabetic nephropathy, we retrospectively analyzed 112 patients with juvenile diabetes with nephropathy. The average age of onset of diabetes in this group of patients was 12 ± 8 years, the average duration of diabetes mellitus when proteinuria was 17.3 ± 6.0 years, early renal failure occurred 2 years after proteinuria, severe renal 4 years after proteinuria Failure (average serum creatinine concentration 8.5 ± 3.9 mg%). The average survival time after proteinuria was 4.8 years (up to 13.3 years). The average survival time after the onset of early renal failure was 2.7 years (up to 5.7 years). The average survival time after severe renal failure was 6 months. The death rate of this group of patients was 53%, 59% of fatal cases died of renal failure, 36% died of cardiovascular disease. Progressive renal dysfunction and diabetes mellitus occurred in all patients