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目的探讨血管内皮生长因子(vascular endothelial growth factor,VEGF)+936TC基因多态性和子宫内膜异位症遗传易感性的关系。方法检索MEDLINE、EMBASE以及中国生物医学文献数据库、万方数据库等中、英文数据库公开发表的关于VEGF+936TC基因多态性和子宫内膜异位症遗传易感性的文献。对文献进行质量评价、筛选和提取相关病例对照研究资料,利用Revman5软件进行Meta分析,计算合并的比数比(odds ratio,OR)及其95%可信区间(confidence interval,CI)。结果共纳入文献5篇,累计病例组1784例,对照组1865例。以携带+936TC基因型的个体患子宫内膜异位症的风险显著增加:杂合子模型(OR=1.19,95%CI:1.02-1.37,P=0.02,heterogeneity:I2=3%)、主导模型(OR=1.18,95%CI:1.03-1.37,P=0.02,heterogeneity:I2=27%)。结论 VEGF+936TC基因多态性可增加子宫内膜异位症的遗传易感性。
Objective To investigate the relationship between the gene polymorphism of vascular endothelial growth factor (VEGF) + 936TC and genetic susceptibility to endometriosis. Methods MEDLINE, EMBASE and Chinese biomedical literature database, Wanfang database and other published in the English database on the gene polymorphism of VEGF + 936TC and genetic susceptibility to endometriosis literature. The quality of the literature was evaluated, and the relevant case-control data were screened and extracted. Meta-analysis was performed using Revman5 software to calculate the combined odds ratio (OR) and its 95% confidence interval (CI). Results A total of 5 articles were included in the literature, with 1784 cases in total and 1865 cases in control group. The risk of endometriosis in individuals carrying the +936 TC genotype was significantly increased: heterozygous (OR = 1.19, 95% CI: 1.02-1.37, P = 0.02, heterogeneity: I2 = 3% (OR = 1.18, 95% CI: 1.03-1.37, P = 0.02, heterogeneity: I2 = 27%). Conclusion The gene polymorphism of VEGF + 936TC may increase the genetic susceptibility of endometriosis.