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肾癌源自肾实质泌尿小管上皮系统,全球范围内肾癌的发病趋势逐年增高.在我国具有较高的发病率,大部分患者明确诊断时已是晚期,给患者带来巨大的经济负担.随着自噬理论的逐渐完善,相关机制已成为治疗众多疾病的理论依据,同时发现自噬现象在肾癌中普遍存在,近年来诸多与自噬通路相关的药物陆续应用于肾癌的治疗,并获得一定的短期疗效,但远期效果仍然存在争议.本文就肾癌与自噬相关的通路、基因、蛋白质以及治疗药物方面作一综述.“,”Renal cell cancer derived from renal parenchyma urinary tubular epithelial system.In the worldwide,the trend of renal cell cancer increases year by year.It also has a high incidence in China.It was too late,when the majority of patients were diagnosed as advanced cancer,which brought huge economic burden to our people.With the gradual perfection of autophagy theories,autophagy mechanisms become the basis of many human diseases treatment.Through the study of kidney cancer,it was found that autophagy was widespread in the kidney.Recently,many drugs associated with autophagy pathway have been applied in the treatment of renal cell carcinoma,and gain a certain effect.But the long-term effects remain controversial.In this paper,we make a review about renal cell carcinoma and autophagy-related pathways,genes,proteins and the treatments.