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糖尿病(DM)性植物神经功能障碍临床常见,其起病隐匿,表现复杂,早期易误诊、漏诊.为提高临床诊疗水平,本文参考文献,结合作者实践,就DM性植物神经功能障碍的发生与发展因素、主要临床表现、早期发现和治疗预防对策等问题讨论如下.1 DM性植物神经功能障碍的发生与发展因素DM性神经病变,由于患者血糖长期增高,糖代谢障碍,山梨醇途径活跃,神经细胞肌醇减少和Na~+-K~+-ATP酶活性降低,导致神经细胞动作电位急剧下降,生理生化过程紊乱及电解质失衡;再加上脂类代谢障碍和微血管病变等,最终导致神经结构和功能异常,而引发DM性脑、脊髓、颅神经、周围神经和植物神经病变.植物神经病变常与周围神经病变并存,病变可在交感和副交感神经的传入支、中枢或传出支,也可在感受器或
Diabetic (DM) autonomic dysfunction is clinically common, its onset is insidious, complex performance, early misdiagnosis, missed diagnosis.To improve the clinical diagnosis and treatment level, this paper references, combined with the author’s practice, on the occurrence of DM with autonomic dysfunction and Developmental factors, the main clinical manifestations, early detection and treatment of prevention measures and other issues discussed below.1 The occurrence and development of DM-induced autonomic dysfunction DM neuropathy, due to long-term elevated blood glucose, glucose metabolism disorder, active sorbitol pathway, Decreased inositol content and Na ~ + -K ~ + -ATPase activity in nerve cells lead to a sharp decline in the action potential of neurons, physiological and biochemical disorders and electrolyte imbalance; coupled with lipid metabolism and microvascular disease, eventually leading to nerve Structure and function abnormalities, and lead to DM brain, spinal cord, cranial nerves, peripheral nerves and autonomic neuropathy.Pyzal neuropathy often coexist with peripheral neuropathy, lesions can be sympathetic and parasympathetic afferent branches, central or efferent branch Also available on susceptors or