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〔目的〕探讨乙肝病毒外膜大蛋白监测应用在健康体检中的价值及意义,为今后应用在出国劳务人员健康体检中探寻理论依据。〔方法〕通过对乙肝病毒外膜大蛋白的结构和功能的阐述,分析其检测技术的发展,探讨其在健康体检中的应用价值。〔结果〕乙肝病毒外膜大蛋白与DNA检测结果具有高度的正相关性,比现在使用的乙肝两对半指标更能反应慢性无症状乙肝病毒携带者体内病毒的复制状态。〔结论〕乙肝病毒外膜大蛋白检测可以作为判断肝内病毒继续复制或复制活跃程度的指标,在出国劳务人员健康体检中具有较高的应用价值,有助于体检单位评价体检者的健康状态。
[Objective] To explore the value and significance of hepatitis B virus outer membrane large protein monitoring in the health examination, and to explore the theoretical basis for the future health examination of laborers abroad. [Methods] By analyzing the structure and function of hepatitis B virus outer membrane large protein, the development of its detection technology was analyzed and its application value in health examination was discussed. [Results] The results showed that hepatitis B virus outer membrane large protein had a highly positive correlation with DNA test results, which could better reflect the replication status of virus in chronic asymptomatic hepatitis B virus carriers than the two pairs of semi-indicators of hepatitis B currently used. [Conclusion] Detection of hepatitis B virus outer membrane large protein can be used as an index to determine the extent of replication or replication of virus in the liver, which is of high value in the health examination of labor service workers abroad, which helps the physical examination unit to evaluate the health status of the examinee .