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癌症及其治疗中常伴粒细胞减少症(GCP)。非髓性白血病常伴发 GCP。更常见的是,癌患者接受化疗或放疗后发生骨髓抑制和 GCP,除了粒细胞减少外,白细胞的趋化性、吞噬功能、杀菌力发生障碍。癌的治疗中,一些药物如皮质类固醇、长春新碱、鸦片类等能抑制粒细胞边集和吞噬活动。白血病儿童颅部和脊髓照射可降低白细胞的杀菌力。单核一巨噬细胞(Mφ)除具吞噬功能外,在细胞免疫和体液免疫中也起着作用。皮质类固醇可使 Mφ减少和杀灭霉菌和分枝杆菌的能力降低;使 GCP 患者的细胞吞噬功能进一步障碍。某些癌症如淋巴瘤可影响 Mφ的趋化性和杀菌力。Hodgkin 氏病常伴细胞
Cancer and its treatment are often associated with neutropenia (GCP). Non-myeloid leukemia often associated with GCP. More commonly, cancer patients undergo myelosuppression and GCP following chemotherapy or radiotherapy, with the exception of neutropenia, leukocyte chemotaxis, phagocytosis, and sterility. In the treatment of cancer, some drugs such as corticosteroids, vincristine, opiates and the like can inhibit granulocyte border and phagocytic activity. Leukemia children’s skull and spinal cord irradiation can reduce the leukocyte bactericidal power. Monocyte-macrophage (Mφ) plays a role in cellular immunity and humoral immunity in addition to phagocytosis. Corticosteroids decrease Mφ and reduce the ability to kill mold and mycobacteria; further impair phagocytosis in GCP patients. Some cancers, such as lymphomas, can affect chemotaxis and bactericidal activity of Mφ. Hodgkin’s disease is often accompanied by cells