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在海拔４３００ｍ地区，对１８名移居汉族、２４名世居藏族和２１名高原红细胞增多症（ＨＡＰＣ）患者测定了２，３—二磷酸甘油酸（２，３—ＤＰＧ）和肺通气功能，并进行了血气分析。结果显示：ＨＡＰＣ患者的全血和红细胞内２，３—ＤＰ６浓度均显著高于健康组，但世居、移居健康组之间无明显差异。ＨＡＰＣ组的红细胞２，３—ＤＰＧ和Ｐｄｏ＿２呈显著负相关（ｒ＝—０．７７１，Ｐ＜０．０１），而在健康组无显著相关（ｒ＝—０．２６，Ｐ＞０．０５）。ＨＡＰＣ组与健康组相比，ｐＨ、Ｐａｏ＿２和Ｓａｏ＿２降低，Ｐａｃｏ＿２和肺泡动脉氧分压差增高。ＨＡＰＣ病人Ｐ＿（５０）为３．７５±０．６６ｋＰａ，健康组为３．４０±０．１２ｋＰａ（Ｐ＜０．０５），Ｐ＿（５０）与２，３－ＤＰＧ呈正相关（ｒ＝０．５９２，Ｐ＜０．０５）。ＨＡＰＣ组最大呼气中段流量和５０％肺活量最大呼气量明显低于健康组（Ｐ＜０．０１）。本研究提示：①ＨＡＰＣ患者的低氧血症可能与血中２，３－ＤＰＧ浓度过高有关；②轻度肺功能异常亦可促使红细胞进一步增多。
2,3-diphosphoglycerate (2,3-DPG) and pulmonary ventilation were measured in 4300m above sea level in 18 migrant Han Chinese, 24 Chinese natives and 21 HAPC patients. Blood gas analysis was performed. The results showed that: HAPC patients with whole blood and erythrocyte 2,3-DP6 concentrations were significantly higher than healthy group, but the resident, migrant health group no significant difference. There was a significant negative correlation between erythrocyte 2,3-DPG and Pdo_2 in HAPC group (r = -0.771, P <0.01), but not in healthy group (r = -0.26, P> 0.05 ). HAPC group compared with the healthy group, pH, Pao_2 and Sao_2 decreased, Paco_2 and alveolar artery oxygen difference increased. The P_ (50) of HAPC patients was 3.75 ± 0.66 kPa, while the healthy group was 3.40 ± 0.12 kPa (P <0.05). The P_ (50) was positively correlated with 2,3-DPG. 592, P <0.05). The maximum expiratory flow and maximum expiratory volume at 50% of the HAPC group were significantly lower than those of the healthy group (P <0.01). This study suggests that: ①HAPC patients with hypoxemia may be related to the blood 2,3-DPG concentration is too high; ② mild lung dysfunction can also promote further increase in red blood cells.