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目的:探讨长沙地区手足口病的病原学特征,为当地的疾病预防和控制提供科学依据。方法:使用肠道通用和EV71、CAl6特异性引物,对2009年长沙市的115例手足口病患者的疱疹液、粪便、咽拭子标本,进行RT-PCR鉴定,并对手足口病疫情开展监测,采用流行病学方法对结果进行统计分析。结果:在采集到标本的115例患者中,84例患者检测结果为阳性,其中19例检测为EV71病毒核酸阳性(22.62%);30例检测CAl6阳性(35.71%);35例检测到其他肠道病毒(41.67%)。阳性标本中男女性别比为(1.27:1),发病年龄主要集中1-5岁儿童(90.47%),尤其是在3岁组(34.52%);发病季节主要集中于4-8月。结论:在长沙地区手足口病易发于1-5岁儿童,应在春夏季重点加强这一人群的预防和控制措施。
Objective: To explore the etiological characteristics of hand-foot-mouth disease in Changsha and provide a scientific basis for local disease prevention and control. Methods: Herpes simplex, faeces and throat swab specimens from 115 cases of hand-foot-mouth disease in Changsha in 2009 were identified by RT-PCR using universal gut and EV71, CAl6 specific primers. Monitoring, using epidemiological methods for statistical analysis of the results. Results: Out of the 115 patients collected, 84 patients were positive, of which 19 were positive for EV71 virus (22.62%), 30 were positive for CAl 6 (35.71%), 35 were other intestinal Road virus (41.67%). The positive rate of male to female sex ratio was (1.27: 1). The age of onset mainly concentrated in children aged 1-5 years (90.47%), especially in the age group of 3 years (34.52%). The onset season mainly concentrated in April to August. CONCLUSIONS: Hand-foot-mouth disease in Changsha is most likely to occur in children aged 1 to 5 years. The prevention and control measures for this population should be emphasized in spring and summer.