Tyrosine 23 Phosphorylation of Annexin A2 Promotes Proliferation, Invasion, and Stat3 Phosphorylatio

• 作 者: Yu-qing Wang Fei Zhang Ran Tia
• 机 构: TianjinMedicalUniversityCancerInstituteandHospital,KeyLaboratoryofCancerPreventionandTherapy,KeyLabo
• 出 处: 临床肿瘤与癌症研究：英文版
• 发表日期: 2012年4期
• 关键词: 细胞增殖 STAT3 膜联蛋白 磷酸化 乳腺癌 酪氨酸 侵袭 STAT3 Annexin A2 tyrosine mutation phosphoryla
• 基金项目: supported by grants from the Changjiang Scholars and Innovative Research Team of the University in China(No.IRT1076),the National Natural Science Foundation of China(No.81071731),the Tianjin Science a

<正>Objective To investigate the role of tyrosine 23(Tyr23) phosphorylation of Annexin A2(Anxa2) in regulating the proliferation and invasion of human breast cancer SK-BR-3 cells. Methods A panel of lentivirus plasmids expressing Anxa2-wide type(Ana2