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目的 探讨单一局部复发或远处转移病灶乳腺癌患者行手术治疗的疗效.方法 选取单一局部复发或远处转移病灶的乳腺癌患者90例,由患者自行选择治疗方法,对照组49例,采用以化疗为主的综合治疗措施;观察组41例,在对照组的基础上予以手术切除复发或远处转移病灶.治疗结束1周后,比较两组的近期客观疗效;随访2年(死亡患者以截尾数据统计),比较患者的总生存时间(OS)、无进展生存期(PFS).结果 观察组与对照组有效率受试者分别为40例、47例.观察组与对照组RR分别为8750%、6809%(X2=460,P<005),DCR分别为9500%、8085%(X2=392,P<005).经LogGRank检验,观察组中位OS(95%CI:162~265个月vs.102~236个月)、中位PFS(95%CI:126~208个月vs.89~167个月)均长于对照组(P<005).结论 手术治疗单一局部复发或远处转移病灶的乳腺癌患者具有积极的临床意义,不仅改善了临床症状,具有较高的近期客观疗效,且提高了生存期,优于综合保守治疗的效果,对于其临床治疗具有一定的借鉴意义.
Objective To investigate the curative effect of surgical treatment in patients with single local recurrence or distant metastasis of breast cancer.Methods 90 patients with breast cancer who had a single local recurrence or distant metastasis were selected by the patients and the control group was treated by Chemotherapy-based comprehensive treatment measures; observation group 41 cases, based on the control group to be surgical resection or distant metastasis lesions after 1 week after the end of the treatment, the two groups were compared the recent objective effect; follow-up 2 years (OS) and progression-free survival (PFS) were compared between the observation group and the control group.Results The effective rate of observation group and control group were 40 cases and 47 cases respectively.The RR of observation group and control group were respectively (95% CI: 162 ~ 857) were 8750%, 6809% (X2 = 460, P <005) .The DCR were 9500% and 8085% (P <0.05). The median PFS (95% CI: 126-208 months vs. 89- 167 months) was longer in the control group than in the control group (P <0.05) .Conclusions Surgical treatment of a single local recurrence or Breast cancer patients with distant metastases have a positive clinical significance, not only improve the clinical symptoms, have a high objective and immediate effect, and increased Deposit term, the effect is better than conservative treatments, with some reference for clinical treatment.