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目的:比较黄体期补充雌激素对卵巢低反应患者的影响。方法:60名卵巢低反应患者,30例在促排卵前黄体期给予雌二醇每天2mg,30例给予安慰剂。结果:使用雌二醇的妇女可以获得HCG日较厚的子宫内膜,更高的获卵数(P<0.05),更多的成熟卵母细胞(P<0.05),更高的受精率(P<0.05)和更多的优质胚胎(P<0.01)。两组启动日窦卵泡数、促排卵时间和临床妊娠率差异无统计学意义。结论:卵巢低反应患者促排卵前黄体期补充雌二醇可以提高IVF-ET优质胚胎数目和胚胎质量,增加子宫内膜厚度,从而可能提高妊娠率。
OBJECTIVE: To compare the effects of estrogen replacement during luteal phase on patients with low ovarian response. Methods: 60 patients with low ovarian response, 30 patients were given estradiol 2mg daily before ovulation induction and 30 patients were given placebo. RESULTS: Women who received estradiol received thicker endometrium on day HCG, higher numbers of oocytes retrieved (P <0.05), more mature oocytes (P <0.05), and higher fertilization rates ( P <0.05) and more high quality embryos (P <0.01). There was no significant difference in the number of primordial follicles, ovulation induction time and clinical pregnancy rate between the two groups. CONCLUSIONS: Ovarian low response patients with pre-ovulation luteal phase with estradiol can improve the quality of IVF-ET embryos and embryo quality, increase the thickness of the endometrium, which may improve the pregnancy rate.