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抗精神病药物(APD)、抗抑郁药、抗癫痫药、类固醇和胰岛素等多种药物均可引起体重增加。前三者致体重增加的机制主要涉及多种神经递质受体介导的食欲增加、能量消耗减少、内分泌及代谢紊乱等多个方面,APD源性肥胖还与遗传基因缺陷有关;而类固醇和胰岛素致肥胖则与脂质代谢失常有关。药物相关性肥胖的防治包括宣传教育、选择合适的治疗方案、营养与行为疗法、加强锻炼,必要时应用一些减轻体重的药物等。
Anti-psychotic drugs (APD), antidepressants, antiepileptic drugs, steroids and insulin and other drugs can cause weight gain. The mechanism of weight gain in the first three diseases mainly involves the increase of appetite mediated by many neurotransmitter receptors, energy consumption reduction, endocrine and metabolic disorders, etc. APD-derived obesity is also associated with genetic defects; while steroid and Insulin-induced obesity is associated with lipid metabolism disorders. Drug-related prevention and treatment of obesity, including publicity and education, the choice of appropriate treatment options, nutrition and behavioral therapy, exercise, if necessary, the application of some weight-loss drugs.