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以红紫素-18甲酯为起始原料,通过外接环的胺解反应转化成氮上连有含羟基或者酰基取代结构的红紫素-18二酰亚胺,利用其周环上的活性反应区域,通过氧化、空气氧化、游离基取代和亲核取代反应,在3-,12-和20-meso-位上分别引进了羟基、酰基或者带有相应官能结构的取代基团,完成了12个未见报道的具有红紫素-18二酰亚胺的叶绿素类二氢卟吩衍生物的合成,其化学结构均经UV,IR,1H NMR及元素分析予以证实;同时也讨论了不同位置的羟基化和酰基化对四吡咯大环所形成的不同影响.
In this method, purpuric-18 methyl ester is used as a starting material and is converted into nitrogen-linked purpurin-18 imide with a hydroxyl group or an acyl substituted structure through an aminolysis reaction of an external ring. Utilizing the activity on the pericyclic ring In the reaction zone, hydroxyl, acyl or substituted groups with the corresponding functional structures are introduced at the 3-, 12- and 20-meso-positions by oxidation, air oxidation, radical substitution and nucleophilic substitution, respectively. The previously reported synthesis of chlorin chlorin derivatives with purpurin-18 imide was confirmed by UV, IR, 1H NMR and elemental analysis. Different positions The different effects of hydroxylation and acylation on tetrapyrrole macrocycles.