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血中谷胱甘肽、某些蛋白质、酶和血红素中都含有相当量的巯基化合物,蛋白质中的巯基(-SH)是活性基团之一,构成酶蛋白的辅基,参与体内的主要代谢活动,具有重要的生物学意义。但由于巯基活性受到各种因素的影响,如当机体患有某些传染病时易引起体内-SH活性发生变化,同样,当机体受到某些工业毒物如Pb,Hg等的影响时,也能导致机体内-SH活性发生变化,因此测定血清中巯基含量对某些参与有害物质作业的工人的职业中毒诊断具有一定的意义。
Glutathione, some proteins, enzymes and heme contain considerable amounts of sulfhydryl compounds. One of the active groups is sulfhydryl (-SH) in proteins, forming a prosthetic group of the enzyme protein involved in the metabolism of the body Activity, has important biological significance. However, due to the mercapto activity by a variety of factors, such as when the body suffers from certain infectious diseases easily lead to changes in vivo -H activity, the same, when the body is subject to certain industrial toxicants such as Pb, Hg, etc., can Resulting in changes in the body-sH activity, so the determination of serum thiol content for some workers involved in hazardous materials occupational poisoning diagnosis has a certain significance.