论文部分内容阅读
将131例入选的早期糖尿病肾病患者随机分为3组,硫辛酸组,厄贝沙坦组,联合组。每组均给予相同饮食、运动、教育、控制血糖及血压、调脂等对症处理。联合组在此基础上采用硫辛酸注射液联合厄贝沙坦治疗,对照组单纯用硫辛酸注射液或厄贝沙坦治疗,疗程均为2周,分别于治疗前后检测24h尿微量白蛋白、糖化血红蛋白、血清尿素氮(BUN)、血清肌酐(SCr)的变化指标。结果治疗后,3组治疗前后24小时尿微量白蛋白均显著降低,硫辛酸组与厄贝沙坦组之间无明显统计学差异(P>0.05),但联合组与硫辛酸组间有明显统计学差异(P<0.05)。结论硫辛酸注射液与厄贝沙坦联合治疗糖尿病肾病方案可明显降低24小时尿微量白蛋白,对尿蛋白改善优于单纯使用硫辛酸注射液或厄贝沙坦治疗糖尿病肾病。提示硫辛酸和ATⅡ受体拮抗药联用有协同作用。
131 cases of patients with early diabetic nephropathy were randomly divided into three groups, lipoic acid group, irbesartan group, combined group. Each group were given the same diet, exercise, education, control of blood sugar and blood pressure, lipid-lowering and other symptomatic treatment. On this basis, the combination group was treated with lipoic acid injection combined with irbesartan, the control group with lipoic acid injection alone or irbesartan treatment for 2 weeks, 24h urine microalbuminuria were detected before and after treatment, Glycated hemoglobin, serum urea nitrogen (BUN), serum creatinine (SCr) changes in indicators. Results After treatment, urinary albumin in 24 hours before and after treatment was significantly lower in the three groups (P> 0.05), but there was no significant difference between the lipoic acid group and the irbesartan group Statistical difference (P <0.05). Conclusion The combination of lipoic acid injection and irbesartan in the treatment of diabetic nephropathy can significantly reduce 24-hour urine microalbuminuria, which is superior to urinary protein in the treatment of diabetic nephropathy by simply using lipoic acid injection or irbesartan. Tip lipoic acid and AT Ⅱ receptor antagonists combined with synergistic effect.