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目的：观察阿莫西林＿克拉维酸钾对恶性血液病化疗后白细胞减少期并发细菌感染的疗效。方法：恶性血液病化疗后白细胞减少期病人６０例（男性３６例，女性２４例，年龄４２ａ±ｓ１５ａ），随机分为２组（每组３０例）。治疗组用阿莫西林＿克拉维酸钾０．６２５ｇ，ｐｏ，ｂｉｄ，对照组用阿莫西林０．５ｇ，ｐｏ，ｑｉｄ，疗程均为５～７ｄ。结果：治疗组和对照组的临床有效率分别为９３％和６０％，细菌清除率分别为８６％和５２％。结论：阿莫西林＿克拉维酸钾是一种有效的治疗细菌感染的药物，无明显的不良反应。
OBJECTIVE: To observe the efficacy of amoxicillin and potassium clavulanate in leukopenia complicated with bacterial infection after chemotherapy for hematological malignancy. Methods: Sixty patients (36 males and 24 females, age 42a±s15a) were treated with leukopenia after chemotherapy for hematologic malignancy and randomly divided into 2 groups (30 in each group). The treatment group used amoxicillin _ clavulanate potassium 0.625g, po, bid, the control group with amoxicillin 0.5g, po, qid, course of treatment is 5 ~ 7d. Results: The clinical effectiveness of the treatment and control groups were 93% and 60%, respectively, and the bacterial clearance rates were 86% and 52%, respectively. CONCLUSIONS: Amoxicillin_potassium clavulanate is an effective drug for the treatment of bacterial infections with no apparent adverse effects.