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临床研究表明,在糖尿病患者中,冠状动脉心脏病的发病率较高,其中胰岛素可能起着关键性作用。我们选择正常大鼠作为研究对象,试图通过胰岛素对肝脏处理胆固醇(TC)、甘油三酯(TG)和对血清TC、TG、高密度脂蛋白胆固醇(HDL-C)的影响,较全面地讨论胰岛素对脂质代谢的调节作用。 正常大鼠血清TC、TG和HDL-C的含量不受饮食与否的影响。因此,我们的实验可在不禁食条件下进行,从而避免了给胰岛素的大鼠在空腹采血或取肝脏时由于低血糖休克而造成死亡。 正常大鼠血清TC、TG和HDL-C分别为96.7+10.7、27.6±8.8和64.2±7.6 mg％,于皮下注射胰岛素后(剂量每日1.5 u/kg,共8天)分别下降至83.9±14.7、20.2±8.0和54.94±10.1 mg％,二者
Clinical studies have shown that in diabetic patients, the incidence of coronary heart disease is higher, of which insulin may play a key role. We chose normal rats as subjects to try to discuss more fully the effects of insulin on liver cholesterol (TC), triglycerides (TG) and serum TC, TG and HDL-C levels Regulation of insulin on lipid metabolism. Normal rats serum TC, TG and HDL-C content from the diet or not. Therefore, our experiments could be performed without fasting, thus avoiding the death of rats given insulin on fasting blood or liver due to hypoglycemic shock. The serum levels of TC, TG and HDL-C in normal rats were 96.7 ± 10.7,27.6 ± 8.8 and 64.2 ± 7.6 mg%, respectively, and decreased to 83.9 ± 10% after subcutaneous injection of insulin (1.5 u / kg daily for 8 days) 14.7, 20.2 ± 8.0 and 54.94 ± 10.1 mg%, both