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目的探讨运动饮食干预配合胰岛素与沙格列汀治疗2型糖尿病对患者相关血清水平的影响。方法将200例2型糖尿病患者随机分为研究组和对照组各100例。对照组应用胰岛素与沙格列汀治疗,研究组在对照组的基础上配合运动饮食干预。比较2组白介素-10(IL-10)、白介素-18(IL-18)、总胆固醇(TC)和三酰甘油(TG)水平。结果治疗前2组IL-10、IL-18、TC和TG水平差异无统计学意义(P>0.05)。治疗后2组IL-10、IL-18、TC和TG水平均低于治疗前,且研究组均低于对照组,差异均有统计学意义(P<0.05)。结论运动饮食干预配合胰岛素与沙格列汀治疗2型糖尿病,能有效改善相关血清指标的水平,相对于单纯使用胰岛素与沙格列汀的治疗疗效更显著,值得推广应用。
Objective To investigate the effects of exercise and diet intervention with insulin and saxagliptin on type 2 diabetes in patients with related serum levels. Methods 200 patients with type 2 diabetes were randomly divided into study group and control group with 100 cases each. The control group was treated with insulin and saxagliptin, and the study group was treated with exercise and diet intervention on the basis of the control group. The levels of interleukin-10 (IL-10), interleukin-18 (IL-18), total cholesterol (TC) and triglyceride (TG) Results There was no significant difference in the levels of IL-10, IL-18, TC and TG between the two groups before treatment (P> 0.05). The levels of IL-10, IL-18, TC and TG in the two groups after treatment were lower than those before treatment, and the levels of IL-10, IL-18 and TC in the study group were lower than those in the control group (P <0.05). Conclusion Exercise and diet interventions combined with insulin and saxagliptin in the treatment of type 2 diabetes mellitus can effectively improve the level of related serum indexes, which is more significant than the simple treatment with insulin and saxagliptin. It is worth popularizing and applying.