Studies on Anti-core Endotoxin Monoclonal Antibodies and Their Protective Effects

• 作 者: 严共华
• 机 构: InstituteofMicrobiologyandEpidemiologyAcademyofMilitaryMedicalScience,Beijing100071,P.R.China
• 出 处: 高技术通讯：英文版
• 发表日期: 1996年2期
• 关键词: MONOCLONAL antibody IMMUNOTHERAPY GRAM-NEGATIVE infection E.COLI Endotoxin. Anti
• 基金项目: a key project of military medical science of the Army

Seven anti-core-LPS Mabs have been prepared with E.coli J5 mutant as an antigen.Fiveare of IgM/κ,one IgG2b/λ,and one IgG3/λ.The five Mabs of IgM are studied for specifici-ty,cross-reactivity,purification and protection.They have broad cross-reactivity in