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[目的] 探讨溃疡“完全愈合”的组织学特征。[方法] 观察大鼠乙酸胃溃疡形成后 5、30、126 d 3 个时间段再生黏膜的病理组织学变化及西咪替丁、柴胡桂枝汤(CHGZT)对其影响。[结果] ①第 5 天 CHGZT组溃疡边缘胃体腺颈部,可见 CHGZT 溃疡伴随细胞系(UACL)增殖、移行,其基底部去分化壁细胞广泛分布;第 30 天CHGZT UACL形如芽状,壁细胞罕见;第126天CHGZT UACL明显分化,呈现泌酸腺雏形。②第 30 天 CHGZT组含CHGZT UACL的标本数与模型对照组相比,差异有统计学意义(P<0.05)。③第 30 天胃体侧的 CHGZT UACL的高度与同一切面再生黏膜高度呈正相直线相关关系( r=0.778, P<0. 01);第 30 天 CHGZT组胃体侧再生黏膜高度与正常组胃体黏膜高度相比,差异无统计学意义。[结论] 壁细胞去分化增殖、再分化重构泌酸腺,是胃体溃疡“完全愈合”的组织学特征。
[Objective] To investigate the histological characteristics of ulcer “complete healing”. [Method] The histopathological changes of regenerative mucosa and the effects of cimetidine and Chaihu Guizhi Decoction (CHGZT) on rat gastric ulcer at 5,30,126 days were observed. [Results] ① On day 5, the CHGZT ulceration associated with UACL cell line (UACL) proliferated and migrated, and the dedifferentiated parietal cells were widely distributed in CHGZT group. On the 30th day, the shape of CHGZT UACL was bud- Parietal cells rare; 126 days CHGZT UACL significantly differentiated, showing oxyntic gland embryo. ② The number of CHGZT UACL samples in CHGZT group on the 30th day was significantly higher than that in the model control group (P <0.05). ③ On the 30th day, the height of CHGZT UACL on the corpus side was positively correlated with the same mucosa (r = 0.778, P <0.01) Gastric mucosa compared to the height, the difference was not statistically significant. [Conclusion] The parietal cells dedifferentiate and proliferate and re-differentiate and reconstruct the oxyntic gland, which is the histological feature of “complete healing” of gastric ulcer.