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目的:探讨C-反应蛋白(CRP)在早产儿院内感染中的动态变化及应用。方法:住院190例早产儿(≤35周)院内感染监测中,动态检测其在病程1 d、3 d、7 d、10 d CRP水平。结果:发生院内感染早产儿病程初期CRP明显增高,3 d左右达最高峰,与对照组相比,有显著差异(P<0.01)。经有效治疗后CRP开始下降,7 d左右仍高于正常,与对照组相比,有显著差异(P<0.05)。有效治疗10 d后,CRP基本降至正常,与对照组相比无显著差异。结论:早产儿CRP的动态变化能更敏感地监测到院内感染的发生,对其诊断具较高临床价值。
Objective: To investigate the dynamic changes of C-reactive protein (CRP) in nosocomial infection of premature infants and its application. Methods: 190 hospitalized premature infants (≤35 weeks) were monitored for nosocomial infection and their CRP levels at 1 d, 3 d, 7 d and 10 d were measured dynamically. Results: The CRP level in the early stage of nosocomial infection was significantly higher than that in the control group at 3 days (P <0.01). After effective treatment, CRP began to decline, still higher than normal about 7 days, compared with the control group, there was a significant difference (P <0.05). After 10 days of effective treatment, CRP basically dropped to normal, no significant difference compared with the control group. Conclusion: The dynamic changes of CRP in preterm infants can detect the nosocomial infection more sensitively and have high clinical value for diagnosis.