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[目的]探讨宫颈癌及食管癌组织中人乳头状瘤病毒(HPV)感染及其基因型分布的相关性。[方法]采用基因芯片方法分别检测200例宫颈癌和140例食管癌的HPV基因型,计算HPV感染率,分析HPV基因型与癌肿类型的关系。[结果]200例宫颈癌的HPV阳性率为94.00%(188/200),共检测到9种HPV基因型,其中主要基因型为HPV16(74.00%)和HPV18(16.00%),HPV双重感染的阳性率达12.00%(24/200)。169例宫颈鳞癌的HPV阳性率为95.86%,显著高于腺癌的80.00%(χ2=9.73,P<0.01),但HPV16、18和HPV双重感染在鳞、腺癌中的阳性率无显著性差异。在140例食管癌组织中,未检测到任何基因型别的HPV。[结论]宫颈癌组织的HPV感染型别多样,HPV16、18为最常见类型,HPV感染更常见于宫颈鳞癌。但HPV各型别的分布与癌肿类型无关,HPV似乎与食管癌的发生无关。
[Objective] To investigate the correlation between human papillomavirus (HPV) infection and genotype distribution in cervical cancer and esophageal cancer. [Methods] The HPV genotypes of 200 cases of cervical cancer and 140 cases of esophageal cancer were detected by gene chip method. The HPV infection rate was calculated. The relationship between HPV genotype and the type of cancer was analyzed. [Results] The positive rate of HPV in 200 cases of cervical cancer was 94.00% (188/200). Nine HPV genotypes were detected, of which the major genotypes were HPV16 (74.00%) and HPV18 (16.00%), The positive rate of 12.00% (24/200). The positive rate of HPV in 169 cases of cervical squamous cell carcinoma was 95.86%, which was significantly higher than that of adenocarcinoma (χ2 = 9.73, P <0.01). However, the positive rates of HPV16,18 and HPV in squamous cell carcinoma and adenocarcinoma were not significant Sex differences. In 140 cases of esophageal cancer, no HPV genotypes were detected. [Conclusion] There are many types of HPV infection in cervical cancer tissues. HPV16,18 is the most common type, and HPV infection is more common in cervical squamous cell carcinoma. However, the distribution of various types of HPV has nothing to do with the type of cancer, HPV seems to have nothing to do with the occurrence of esophageal cancer.